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Micro Diffractometer MD2-S

Like its predecessor MD2, the MD2-S is designed for high precision single crystal diffraction on MX beamlines. The MD2-S features advanced functionalities like in situ screening and an integrated movable beam-stop.

High precision device

Efficient integrated tools

High level of integration

Picture presentation of MD2-S x-ray micro diffractometer

High precision micro diffractometer

1 µm Sphere Of Confusion (SOC)

The MD2-S reaches a 1 µm Sphere Of Confusion (radius, @ 100 deg/s, with a SmartMagnet sample holder mounted on the Ω-axis) with an excellent repeatability and reliability.

This micrometer SOC is achieved by an optimized design combining high precision components with a support structure preventing parasitic vibrations and deformations.

High accuracy

The MD2-S has a high accuracy which is perfectly suited for single crystal X-ray diffractometry and advanced data collection strategies.

The MD2-S reaches a static precision of ± 0.5 mdeg and an excellent dynamic precision of ±2 mdeg for its Ω-axis (@ 10 deg/s rotation speed, with a SmartMagnet sample holder mounted on the Ω-axis).

Enhanced Sample Visualization

Parallax-free sample visualization

The MD2-S integrates ARINAX well-known On-Axis Video microscope (OAV) with an optical axis along the x-ray beam path. The resulting parallax-free image is delivered at high spatial resolution (350  350 nm² per pixel) and excellent contrast.

The outstanding in situ sample imaging is possible thanks to the unique objective design, developed by the European Molecular Biology Laboratory (EMBL).

Video assisted centering system

The MD2-S software offers a video assisted sample centering functionality taking full advantage of the OAV performances. This “three click-centering” functionality gives the possibility to: 

-        Localize the beam

-        Align the sample to the beam position

-        Center the sample within the beam

Intelligent Functionalities

Advanced data collection strategies

The MD2-S software is able to coordinate simultaneously multi-axes movements, the prerequisite for advanced x-ray data collection strategies using grid scans, helical scans or serial crystallography. The control software supports all of these scanning techniques on different levels.

Advanced Detector Trigger modes

The MD2-S diffractometer is compatible with numerous trigger modes to synchronize the different motor positions with the x-ray detector.

The MD2-S diffractometer provides continuously the exact sample position & orientation to the detector which then, are filed for each diffraction image taken by the detector.

Kappa goniometer head & In situ Crystallography

The MD2-S standard SmartMagnet sample holder can be exchanged with different goniometer heads:

To offer the best flexibility to users, the SmartMagnet, the MiniKappa and the Plate Manipulator are designed to be easily mounted and dismounted: switching between these goniometer heads is done within a couple of minutes and no trained personal is necessary.

Integrated Movable Beamstop

The MD2-S integrates a movable beamstop which is optimally suited for single crystal diffraction with a minimum/maximum sample-to-beamstop distance of 8 mm/60 mm. The movable beamstop is also useful for in situ crystallography  with 96-well plates.

Arinax & Beamline Integration

For over 12 years Arinax has developed strong competences in beamline integration. Thanks to its expertise Arinax can entirely integrate the MD2-S into beamline specific software like MXCube or Blu-Ice.The MD2-S software supports different multi-device servers: TINE, TANGO and EPICS.

In addition, the MD2-S is fully configurable for automated beamline operation with 6-axis sample changer robots. ARINAX supplies interface electronics for the communication with sample changer robots from IRELEC-ALCEN.

Scientific Publication

(2017) J Synchrotron Radiat.; 24(Pt 1): 323–332. "P13, the EMBL macromolecular crystallography beamline at the low-emittance PETRA III ring for high- and low-energy phasing with variable beam focusing"

(2016) Acta Crystallogr D Struct Biol.; 72(Pt 3): 413–420."Facilitating best practices in collecting anomalous scattering data for de novo structure solution at the ESRF Structural Biology Beamlines"

Technical Specifications

Arinax x-ray diffractometer MD2-S: table of technical specifications

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